Expression of YAP in the Skin Lesions of Lichen Planus
نویسندگان
چکیده
Objective: To explore the expressions of yes-associated protein (YAP) in skin lesions of lichen planus (LP) and normal skin. Methods: Immunohistochemistry was carried out to quantify the expression of YAP in tissues from the lesions of 30 patients with LP and 30 healthy controls. Results: In normal skin tissues, YAP was slightly expressed in the basal layers of the epidermis, and the positive rate was 26.67% (8/30). In LP, YAP was strongly expressed in the lower layers of the stratum spinosum and some of the infiltrating lymphocytes, and the positive rate was 56.67% (17/30). The expression of YAP in LP was significantly higher than that of normal skin (P < 0.05). Conclusions: YAP may be involved in the occurrence and development of LP.
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